Importantly, C/M@Alb NCs causes higher cell apoptosis of 53.3 ± 5.3% at late stage via synergistic effect between CS and MTX, indicating a significantly higher anticancer efficacy against HT-29 cancer cells due to an enhanced cellular internalization of C/M@Alb NCs via albumin receptors (Fig. 2E and Fig. S16). The gene discussed is ALB; the disease is cancer.