ALB and neoplasm: MTX was rapidly released from C/M@Alb NCs in PBS (pH 5.0) containing high concentration of GSH (~10 mM mimicking tumor cell cytosol environment) as compared to MTX released from C/M@Alb NCs in PBS (pH 7.4) with very low GSH concentration (~2 μM mimicking extracellular matrix) within 48 h (Fig. 1F).