In addition, there are many studies attempting to combine anti‐PD1/PD‐L1 with different targeted therapy, such as tyrosine kinase inhibitors,36, 37, 38, 39, 40 poly (ADP‐ribose) polymerase (PARP) inhibitors (PARPi), chemotherapy,41, 42 antibody‐drug conjugate,43 HPV vaccine,44, 45, 46, 47 and tumor infiltrating lymphocytes.48 Here, CD274 is linked to neoplasm.