HIF1A and neoplasm: Under hypoxic conditions, the expression of HIF‐1α is upregulated, enabling tumor cells to enhance metabolic pathways and antioxidant capabilities to adapt to high ROS concentrations, thereby reducing ROS‐induced cytotoxicity.[18] The weakened mitochondrial function and limited ROS production further decrease ROS effectiveness in tumor therapy.[19] Moreover, hypoxia also activates immune‐suppressive signals, which modulate immune cell functions, promoting immune escape and immune suppression.[20] Simultaneously, the hypoxic microenvironment significantly affects the bone repair process.