ZBP1 (Z‐NA binding protein 1), an important cytosolic nucleic acid sensor and a key downstream effector of the cGAS‐STING pathway, has shown promise in tumor therapy.[23, 24, 25] ZBP1 activates necroptotic pathways and induces cytokine release, enhancing cellular responses to ROS and promoting tumor cell death. Here, CGAS is linked to neoplasm.