PDCD4, a well‐established tumor suppressor and translational repressor, has been implicated in multiple aspects of tumor biology, including initiation, progression, metastasis, and therapeutic responsiveness.[22] Mechanistically, PDCD4 inhibits the activity of eIF4A, thereby disrupting the cap‐dependent translation of a subset of oncogenic and immunosuppressive mRNAs.[23, 46] Notably, a study by Brina et al. This evidence concerns the gene PDCD4 and neoplasm.