SYVN1 and infection: reported that the ER‐associated degradation (ERAD)‐localized E3 ligase 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase degradation 1 (HRD1) targets and mediates the ubiquitination of TGB MPs from both BNYVV and PVX.[14] As infections caused by TMV, BNYVV, and PVX induce ER stress,[53, 54, 55] these findings highlight the essential role of the ERAD system in antiviral defense by degrading viral MPs.