GLO1 and cancer: PARK7 protects against oxidative stress and maintains mitochondrial integrity, key factors in Parkinson's disease.[50] In HEK293 cells, it suppresses ferroptosis by detoxifying MGO and limiting protein glycation and lipid peroxidation.[26] In contrast, our study shows that GLO1 dysfunction—but not PARK7 deficiency—promotes ferroptosis via MGO accumulation in cancer cells, with PJA1‐mediated GLO1 degradation acting as an upstream regulatory mechanism.