A previously reported child with anosmia, partial GH deficiency, hypogonadotropic hypogonadism, and low bone mass carried a different missense variant in GLI2 (p.Tyr176Cys), further illustrating this genotypic and phenotypic heterogeneity (Zhang et al. 2023; Kim et al. 2019). Here, GLI2 is linked to Kallmann syndrome.