In a review of 112 individuals from 65 kindreds with GLI2 variants, only 37% of those with truncating variants had both pituitary anomalies and polydactyly, whereas non‐truncating variants were associated with a pituitary only phenotype in 92% of cases with incomplete penetrance (Bear et al. 2014; Zhang et al. 2023; Fan et al. 2023; Wang et al. 2023). Here, GLI2 is linked to polydactyly.