ADORA2A and renal fibrosis: Indeed, both pro‐inflammatory (M1) and anti‐inflammatory (M2) macrophages contribute to renal fibrosis by secreting distinct sets of cytokines that influence fibroblast activation and extracellular matrix remodeling.[12, 36] Macrophages express both α1/2‐ and β‐ARs,[37] with activation of α2‐ARs known to promote a pro‐inflammatory macrophage phenotype.[38] However, the specific role of individual α2‐AR subtypes remains largely unexplored.