In the TIME, TEVs orchestrate a pro-tumorigenic environment by suppressing the functions of anti-tumor cells, such as CD8 + T cells, CD4 + T cells, γδ T cells, NK cells, B cells, and DCs, and promoting the pro-tumor cells, such as MDSCs, Tregs, and Bregs, and inducing pro-tumor polarization of macrophages, neutrophils, and CAFs. The gene discussed is CD4; the disease is neoplasm.