On assessment of the potential of IMM-AGE score to identify patients with undifferentiated arthritis at risk of developing RA, we observed a significantly higher score in these patients that develop RA [p = 0.041; Fig. 5g]; driven by an expansion of terminally differentiated effector memory [p = 0.042; Fig. 5h] and senescent-like CD4 T cells [p = 0.033; Fig. 5i]. The gene discussed is CD4; the disease is rheumatoid arthritis.