Unsurprisingly the reduction in naïve T cells was balanced by an increase in increased frequency and absolute number of central memory (p = 0.043 and p = 0.0021 respectively) and terminally differentiated EMRA memory CD4 T cells (p = 0.041, p = 0.0033 respectively) in early and established RA compared to healthy controls [Fig. 1b; Supplementary Table S1]. The gene discussed is CD4; the disease is rheumatoid arthritis.