FOXP3 and rheumatoid arthritis: A similar expansion of follicular regulatory (Tfr) cells a sub-population of Foxp3 expressing Tfh cells that can migrate to the germinal centre and inhibit Tfh-mediated B-cell antibody production24 was observed in patients with early and established RA (“p < 0.0001”), but not in patients with arthralgia (p = 0.54) and undifferentiated arthritis (p = 0.41) [Fig. 3f].