A key trait of these senescent-like T cells is the secretion of pro-inflammatory (e.g., TNFα, IL-6) and tissue remodelling factors, termed senescence-associated secretory phenotype (SASP), implemented by Mitogen-activated protein kinases (MAPKs) which may contribute towards the inflammaging observed in patients with RA [Table 2]. Here, WNK2 is linked to rheumatoid arthritis.