Lastly, we saw an increased expression of specific metabolic reprogramming markers such as increased Dual-Specific Phosphatase 4 (DUSP4)33 and loss of Glucose-6-phosphate dehydrogenase (G6PD) in patients with RA [Fig. 5] driving an aged phenotype in T driving their arthritogenic properties. Here, DUSP4 is linked to rheumatoid arthritis.