Here, we aim to compare the BF-VR algorithm to the established FTP-VR method, determine the accuracy of the visual reads compared with semiquantitative assessments of tau PET using SUV ratios (SUVRs), compare how well visual reads and semiquantitative measures correlate with positivity in an independent AD biomarker (phospho-tau 217 [p-tau217]), assess the interrater and intrarater reliabilities of the BF-VR algorithm, and evaluate how well the BF-VR algorithm translates to scans with the tau PET tracer [18F]flortaucipir. Here, MAPT is linked to Alzheimer disease.