This dual modulation of βIII- and βIV-tubulinswas responsible for the unique capability of these compounds to altermicrotubule dynamics and inhibit cancer cell migration and invasiveness.Furthermore, the disruption of FA organization via the mislocalizationof ILK and the consequent interruption of the integrin signaling pathwaysunderscored the multifaceted effects of these compounds. Here, ILK is linked to cancer.