Importantly, novel paclitaxel analogs 1b and 1c significantly reduced βIII-tubulinlevels, leading to markedly slower microtubule polymerization anda consequent reduction in the inclusiveness of colon cancer cells.βIII-tubulin is a protein critically involved in cancer metastasisand is known to be present in invading cell bubbles during colon cancerdevelopment. Here, CACNA1B is linked to malignant colon neoplasm.