From an interventional standpoint, multiple studies have shown improved AM efferocytosis following intratracheal instillation of recombinant Gas6, accompanied by reductions in proinflammatory cytokine production.137, 138In addition, instillation of apoptotic T cells has been shown to accelerate resolution after ALI, which intriguingly suggests that in some injury settings AM may lack target AC to “feed” efferocytosis.132This concept of lacking AC has some support in human patients with ARDS; a recent study found that ARDS neutrophils commit to NET formation rather than apoptosis.128. Here, GAS6 is linked to acute respiratory distress syndrome.