ICD is characterized by the release of damage-associated molecularpatterns (DAMPs), such as calreticulin (CRT) exposure on the cellsurface, translocation of high-mobility group protein B1 (HMGB1) fromthe nucleus to cytoplasm, and secretion of ATP. There are several strategies to induce ICD, among whichthe generation of substantial levels of ROS is one of the most commonand effective. The gene discussed is HMGB1; the disease is impulse control disorder.