The generation of reactiveoxygen species (ROS) was demonstrated to induce immunogenic cell death(ICD), thereby enhancing antitumor immune responses through the recruitmentof CD8+ tumor-infiltrating lymphocytes (TILs), promotionof dendritic cell maturation, and reprogramming of macrophages towardthe proinflammatory M1 phenotype. The gene discussed is CD8A; the disease is neoplasm.