In the pan-cancer cohort, patients with high numbers of intratumoral CD8+ or PD-1+ cells in had significantly lower risks of death compared with those with low numbers (CD8+: high v low hazard ratio [HR], 0.62 [95% CI, 0.48 to 0.81], Wald P = .002; PD-1+: high v low HR, 0.65 [95% CI, 0.51 to 0.83]; P = .0009) after adjusting for risk factors, including cancer type. The gene discussed is CD8A; the disease is cancer.