Although HER2 at baseline was detected mostly in invasive tumor foci (both membranous and cytosolic), we separately scored intraductal foci, because they usually had greater levels of staining, using the maximum H-score for each case to compare trends across the cohort, irrespective of morphology, because the maximum H-score showed a positive correlation with measurements of ERBB2 transcripts per million across 35 IHC-matched laser capture–microdissected foci (Supplemental Figure 2D). The gene discussed is ERBB2; the disease is neoplasm.