In addition, in our recent work on Pstpip2-KO induced autoinflammatory disease, chronic multifocal osteomyelitis, and Ncf2-KO–induced chronic granulomatous disease, we demonstrated that genetic loss of Morrbid mitigated these 2 autoinflammatory diseases too (58, 59). Here, MIR4435-2HG is linked to chronic granulomatous disease.