UBA1 and VEXAS syndrome: Supplemental Tables 1–4 provide 4 angles covering the comparison of various aspects of human VEXAS syndrome and our mouse modeling in detail. Overall, it is persuasive that VEXAS syndrome in humans is induced by the comprehensive and synthetic consequence of somatic, pathogenic, and loss-of-function of UBA1 mutations in HSCs; however, the 9 CKO murine models in the present study recapitulated the effects of Uba1 loss (null mutation) in certain hematopoietic cell types.