VEGFA and cancer: Together, these results further validate the working model illustrated in Figure 5C, in which TG-VHS opsonizes VEGFA and induces VEGFA co-phagocytosis by leveraging HER2 overexpressed on the cancer cell surface via ADCP, which can be mediated by both unpolarized and M1- or M2-polarized BMDMs, a proposed mechanism of VEGFA co-phagocytosis that is not achievable with the parental antibodies alone or in simple combination.