Additionally, elevated TNS3 mRNA levels correlated with decreased migration and invasion in malignant thyroid cell lines [54,55], TNS3 promoter hypermethylation was linked to renal cell carcinoma (RCC) metastasis [56], and mixed-lineage leukemia 3 (MLL3)-activated TNS3 suppressed U2OS cell migration [57]. The gene discussed is TNS3; the disease is hereditary clear cell renal cell carcinoma.