Furthermore, in colorectal cancer cells, the EGFR/Kras pathway specifically upregulates TNS4, though without affecting TNS3 [81,82], and in HeLa cells, the EGFR-activated RAF/MEK/ERK pathway facilitates p300 binding to the TNS4 promoter, enhancing its expression [83]. The gene discussed is TNS3; the disease is colorectal cancer.