In DLC1-expressing cells, like HFFs, H157/H1703 NSCLC cells, and HEK293T cells expressing exogenous DLC1, functional studies suggest that TNS3 acts as an inhibitor of DLC1, thereby enhancing RhoA activity, similarly to TNS1 and TNS2 [15,44]. The gene discussed is TNS1; the disease is non-small cell lung carcinoma.