TNS1 and AL amyloidosis: Point mutations remain exceptionally scarce, with isolated reports including TNS1 variants in peripheral T-cell lymphoma (1/26 patients) [153], a TNS1 p.S1309Y missense mutation associated with enhanced migration in clear cell renal cell carcinoma [154], and a splice-site mutation of TNS1 (NM_022648.7:c.2999-1G > C) identified in a synchronous multiple myeloma/thyroid carcinoma patient [155].