Similarly in head and neck cancers, integrated analysis of TCGA and independent cohorts demonstrated progressive TNS4 upregulation from normal to dysplastic to tumor tissues in head and neck squamous cell carcinoma (HNSCC), where high expression predicted poorer survival, which was validated by significant protein overexpression in 12 paired tumor/normal samples [137]. The gene discussed is TNS4; the disease is head and neck squamous cell carcinoma.