In the spleen at 72 h, there was a negative regulation of chemokines (e.g., cxcl8c and ccl13) and TNF (tnfsf12) both involved in “immune response” and “immune system process”, confirming the intensity of the infection in this tissue (target) and some exhaustion in the attempt for a pro-inflammatory response. Here, TNFSF12 is linked to infection.