EGFR and neoplasm: In vivo, sEV-CH1055-Pep4 produced a high contrast and targeting ability in H1264 tumor-bearing mice, with a TBR of 10.43 at 72 h, which has a much longer retention time in tumor tissue than previous CH1055-PEG1k-Pep4 (Figure 3), showing promise for the non-invasive high-contrast NIR-II fluorescence imaging of EGFR-overexpressing tumors.