RHOA and cancer: Similarly, common hub-genes such as GAPDH, AKT1, EGFR, RHOA, TPI1, SDHA, TFRC, FASN, and HIF1A are reported to be implicated in the oncogenic pathways leading to cancer cells’ proliferation and progression, playing a crucial role in PDAC [52,53,54,55,56,57,58,59,60], while CS is not explicitly reported in PDAC, resulting in a novel PDAC cancer cell marker.