The protein network of unique cancer cell genes in the “cancer-PDAC_vs_all-normal” group showed top 10 hub genes, including FN1, COL1A1, COL1A2, COL3A1, COL5A2, COL6A1, COL5A1, BGN, COL6A2, and FBN1, showing 62, 59, 56, 55, 51, 50, 50, 48, 46, and 45 interactions within the protein network, respectively. This evidence concerns the gene COL3A1 and cancer.