Moreover, all the hub-genes, including FN1, COL1A1, COL1A2, COL3A1, COL5A2, COL6A1, COL5A1, BGN, COL6A2, and FBN1, of the “cancer-PDAC_vs_all-normal” group are reported to be implicated in PDAC patients, leading to poor prognosis [45,46,47,48,49,50,51]. This evidence concerns the gene FBN1 and cancer.