The protein network of unique cancer cell genes in the “cancer cells_vs_all-PDAC” group exhibited top 10 hub genes, including H4C6 (HIST1H4A or HIST1H4C), MYC, H3C12 (HIST1H3A or HIST1H3D), DDX21, USP7, RFC4, APEX1, CDK9, H2BC9 (HIST1H2BH), and NOP2. This evidence concerns the gene NOP2 and cancer.