After 10 weeks of treadmill exercise, the PD mice exhibited a significant improvement in their retention time during the rotation test (Figure 1G, p = 0.002), as well as a notable increase in TH immunoreactivity observed within the SN (p = 0.015) and ST (p < 0.001) regions compared to the sedentary PD mice (Figure 1H,I). The gene discussed is TH; the disease is Parkinson disease.