CASP3 and infection: Flow cytometry demonstrated a marked reduction in both lymphocyte and myeloid cell populations at 33 °C compared to 23 °C within 12 h post-infection (Figure 3E,F); this reduction was associated with the marked upregulation of the caspases-3/7 (Figure 4E,F) and enhanced apoptosis in both lymphocyte and myeloid lineages at 33 °C (Figure 4B,D).