STAT3 and neoplasm: In the JAK-STAT signaling pathway, JAK1 indirectly regulates cell proliferation and apoptosis through activation of downstream STAT factors; the significant downregulation of STAT family member STAT3 and apoptosis-related protein CASP8 indicates that EA-2 may suppress tumor cell proliferation and anti-apoptotic capacity by blocking JAK-STAT3 signaling transduction.