TARDBP and frontotemporal dementia: We re-analyzed a publicly available transcriptomic database study of the frontal cortex from different types of patients with frontotemporal lobar degeneration (FTLD) with TDP-43 pathology (type A, B, C and D) based on postmortem histological TDP-43 location and type of aggregates in different brain areas [35] Both the mice and the different types of FTLD-TDP patients showed the same trend of downregulated genes involved in the cholesterol synthesis and the upregulation of genes involved in cholesterol transport (Fig. 5h).