TARDBP and amyotrophic lateral sclerosis: Indeed, lipid droplet accumulations have been found in the spinal cord of SOD1G93A mice [11], as well as in astrocytes and neurons of TDP-43 transgenic mice and iPSC-derived motor neurons from C9orf72 ALS/FTD patients, further supporting the role of cholesterol dysregulation in TDP-43 proteinopathies [1, 26, 36, 44].