APP and Mental deterioration: Also, a unique transgenic mouse model [Tg-SwDI transgenic mice expressing human Aβ precursor protein (AβPP) harboring the Swedish K670N/M671L and vasculotropic Dutch/Iowa E693Q/D694N mutations in the brain] was developed to investigate the early-onset and robust accumulation of both parenchymal and vascular Aβ and the mechanisms of cerebrovascular dysfunction, neuroinflammation, neurodegeneration, and cognitive decline observed in AD/CAA patients (Davis et al., 2004; Miao et al., 2005; Davis et al., 2006; Xu et al., 2007; Xu et al., 2014; Schiltzova et al., 2017; Robison et al., 2019).