Inflammatory cytokine IL-6 expression leading to impairment of mitochondrial functions in hepatic cells after intracerebral amyloid injection was documented; likewise, increased mitochondrial enzymatic activity in the brain and liver after intravenous mitochondrial transfer in these models was reported, although injected mitochondria were detected in the liver and not in the brain (Nitzan et al., 2019; Sweetat et al., 2023). The gene discussed is IL6; the disease is amyloidosis.