APP and Alzheimer disease: However, the absence of Aβ aggregates in old 3xTg-AD male mice, on the one hand, and lack of the described pathologies, such as splenomegaly, spleen amyloidosis, an increase in neutrophils percentage in the spleen and macrophage percentage in the liver, in age-matched Tg-SwDI mice, another commonly used AD/CAA model, and in other APP transgenic mice reported previously, on the other hand, suggest taking into account the results observed in 3xTg-AD mice with caution to prevent erroneous interpretations due to artifacts.