Interestingly, we and others showed that loci encoding transcription factors such as Batf2, Fos, and Jun, important in myeloid differentiation (Matatall et al., 2016; Liebermann et al., 1998; Taylor et al., 2024) were hypermethylated and transcriptionally repressed in Dnmt3a-mutant HSCs after infection (Hormaechea-Agulla et al., 2021). The gene discussed is DNMT3A; the disease is infection.