Our findings suggest that mtROS production is a critical cellular response in the inflammatory cytokine storm of sepsis, and the cGAS-STING-IFN-β signaling pathway may be a novel therapeutic target for sepsis treatment.IMPORTANCESepsis remains lethal due to an uncontrolled "cytokine storm" damaging organs, yet specific treatments are lacking. This evidence concerns the gene STING1 and Sepsis.