GLP1R and Insulin resistance: In addition, GLP-1 medications are being considered for the treatment of sleep apnea, substance use disorders, neurodegenerative disorders (eg, Parkinson disease and Alzheimer disease), insulin resistance, mental health (eg, anxiety and depression), and other diseases (eg, metabolic dysfunction–associated steatohepatitis with liver fibrosis—formerly referred to as fatty liver disease) [48-50].