In addition, GLP-1 medications are being considered for the treatment of sleep apnea, substance use disorders, neurodegenerative disorders (eg, Parkinson disease and Alzheimer disease), insulin resistance, mental health (eg, anxiety and depression), and other diseases (eg, metabolic dysfunction–associated steatohepatitis with liver fibrosis—formerly referred to as fatty liver disease) [48-50]. This evidence concerns the gene GLP1R and early-onset autosomal dominant Alzheimer disease.