PLN and cardiomyopathy: Subsequently, also studies in mice carrying a genomic PLN-R14del locus reported reduced inhibitory activity on SERCA2a in cardiomyocytes and this was true for both heterozygous and homozygous PLN-R14del mice.9,12 Studies utilizing PLN-targeting antisense therapy could further unravel the impact of PLN silencing on cardiomyocyte calcium handling and SR clustering in PLN-R14del cardiomyopathy, potentially offering deeper insights into the disease mechanism.13