There are three genes of special interest: the PRKN gene, located at 6q25.2–27 (15), which is related to mitochondrial maintenance (12) and the most common mutation of autosomal recessive disease (16); LRRK2, located at 12q12–q13.1 (17), is the most frequent cause of autosomal dominant disease and related to sporadic forms with age-dependent penetrance (16) and functions in transport and protein synthesis (12); and GBA, the gene that codes the enzyme glucocerebrosidase, which is essential to the sphingolipid degradation pathway (16). This evidence concerns the gene GBA1 and autosomal dominant disease.