Similarly, functional loss of Marf caused precocious axon degeneration (Cao et al., 2017), enhances decline in spastic paraplegia models (Fowler and O’Sullivan, 2016), triggers ROS-increase in nephrocytes (Zhu et al., 2024) and leads to ER stress and fragmentation (Debattisti et al., 2014). The gene discussed is MFN2; the disease is Spastic paraplegia.