In Drosophila, Drp1 loss decreases lifespan (Rana et al., 2017), but there seem to be no reports of ROS-induced neurodegeneration; instead Drp1 deficiency was shown to rescue longevity in a proteasome-deficient model (Tsakiri et al., 2019b), and dominant-negative Drp1 was beneficial in ALS models (Altanbyek et al., 2016). This evidence concerns the gene DNM1L and amyotrophic lateral sclerosis.