KDM4A (lysine‐specific demethylase 4A) is a histone demethylase that primarily targets the methylation marks at lysine 9 (H3K9me3) and lysine 36 (H3K36me3) of histone H3, opening chromatin structures through demethylation, which facilitates gene transcription and plays a crucial role in cancer development [153]. Here, KDM4A is linked to cancer.