Diseases with nDNA mutation include myopathy or encephalomyopathy related to coenzyme Q10 deficiency, mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), Leigh syndrome, and a whole host of syndromes associated with mutations such as polymerase gamma (POLG) enzyme, complex 1–5 and carnitine palmitoyltransferase (CPT) [60]. This evidence concerns the gene POLG and mitochondrial neurogastrointestinal encephalomyopathy.