BRCA1 and neoplasm: Supplementary Table S4 provides a clearer summary of the phenotypic differences across epithelial, immune, and stromal compartments by integrating the key findings from multi-omic analyses. Our analysis revealed that immune and stromal components were enriched in the BRCA1-MT group, which was regarded as “hot” tumor. In contrast, the BRCA1-WT group was primarily composed of tumor cells, in line with the features of “cold” tumor (53).