SPP1 and neoplasm: Myeloid cells were subclustered into monocyte, Tumor-associated macrophage (TAM) including SPP1+ TAM, C1Qs+TAM, HSPs+ TAM, ACP5+ TAM, and CCL5+ TAM, classical dendritic cell (cDC) encompassing cDC, CD1A+ DC, LAMP3+ DC and PCLAF+ DC, plasmacytoid DC (pDC) as well as unknown subpopulations (Figure 3A).