MPPE1 and neoplasm: For instance, Jan P. Bottcher’s team identified the intra-tumor cDC1-CD8+ T-cell population as a key component of protective anti-tumor immunity based on RNA-seq and deep learning approaches, and identified a unique population of immune-stimulatory CCR7neg cDC1s that produce CXCL9 to promote CD8+ T cell population recruitment and drive T by cross-presentation of tumor antigen cell differentiation and expansion (52).