Serine protease inhibitor Kazal type 1 (SPINK1), a member of the Kazal-type serine protease inhibitor family, was initially identified in the urine of ovarian cancer patients (11, 12), it is secreted by pancreatic acinar cells into the pancreatic duct, where it inhibits trypsin activity. This evidence concerns the gene SPINK1 and ovarian carcinoma.