In B16F10 tumors, addition of SX-682 containing chow to treatment with palbociclib + PF-07104091 blocked tumor growth and this was accompanied by reduced the percentage of CD8+ T cells, but also reduction in LAG-3+CD8+ T cells, TIM-3+ CD8+ T cells, PD-L1+ CD8+ T cells, Foxp3+CD4+ T cells, and IL-10+ CD4+ T cells in the TME, suggesting the CD8+ T cells were less exhausted compared to those in the control TME. The gene discussed is CD274; the disease is neoplasm.