CASP3 and melanoma: At the 72- and 144-hour time points there were greater increases in caspase 3/7 activity in response to single treatment and combination treatments (Supplementary Figure S1). Notably, the combination of 10 μM palbociclib and 10 μM PF-07104091 resulted in the elimination of melanoma cell viability after 48 hours of drug treatment (Supplementary Figure S1).