It has been found that the expression of TOX, TOX2 protein and TIM3 is elevated in T-cell acute lymphoblastic leukemia (T-ALL), and that TOX and TOX2 proteins can directly induce the transcription and expression of TIM3, preventing apoptosis, whereas targeting TXO or TIM3 slows down the growth of tumors (35). Here, TOX2 is linked to T-cell acute lymphoblastic leukemia.