HAVCR2 and neoplasm: In summary, these findings point to the conclusion that the aberrant expression of TIM-3 in MDS progenitor cells and immune cells builds a complex regulatory network: TIM3 directly inhibits the anti-tumor activity of T/NK cells, promotes the immunosuppressive function of MDSC and M2-type macrophages, and alters the immune-regulatory properties of DC cells and Treg cells.