HAVCR2 and T-cell acute lymphoblastic leukemia: It has been found that the expression of TOX, TOX2 protein and TIM3 is elevated in T-cell acute lymphoblastic leukemia (T-ALL), and that TOX and TOX2 proteins can directly induce the transcription and expression of TIM3, preventing apoptosis, whereas targeting TXO or TIM3 slows down the growth of tumors (35).