Drawing parallels with our work (1), from Figure 1C, we have demonstrated a range of cytokine induction (IL-10, IFNγ, TNFα, IL-17, IL-6 and IL-2) between healthy controls and Bregs taken from lung cancer patients who do and do not develop autoinflammatory sequelae post treatment with checkpoint blockade. This evidence concerns the gene TNF and lung carcinoma.