In addition to altered circulating CS components/proteins, the CR variants, such as CR3 (CD11b/18, Mac-1, or integrin αMβ2) variant M441K, display a trend toward an increased adhesion to iC3b, which is most significantly associated with preeclampsia in the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) cohort (396). The gene discussed is CS; the disease is preeclampsia.