Genetic CFI deficiency is associated with recurrent infections with encapsulated bacteria (i.e., Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae), renal autoimmune diseases, such as C3 glomerulopathy (C3G), atypical hemolytic uremic syndrome (aHUS), and age-related macular degeneration (AMD) (45, 46). This evidence concerns the gene CFI and age-related macular degeneration.