CD46 and systemic lupus erythematosus: In addition to factor H, other C3b regulators, such as MCP and Complement Factor I (CFI) genetic mutants [typically associated with atypical hemolytic uremic syndrome (aHUS)], in pregnant women with systemic lupus erythematosus (SLE) or antiphospholipid antibodies (APL Ab) have been identified, indicating their higher susceptibility to develop preeclampsia than normal women (394).