No genetic deficiency of vitronectin has been reported in humans (87). Vitronectin levels impact severity of bacterial infections by different mechanisms, including affecting CS (88). In mice, systemic vitronectin deficiency delays dermal wound healing, increases areas of delayed hemorrhage, and attenuates hepatic fibrosis in non-alcoholic steatohepatitis mouse model (89, 90). Here, VTN is linked to Hepatic fibrosis.