Recognizes complement component C3b and C4b and inhibits CS signaling pathways (classical, lectin, and alternative).CD55 also serves as receptor for Coxsackieviruses, other enteroviruses, and malaria parasite. CD55 binding to the HIV-1 and hepatitis-C virus (HCV) surface as result of their replication in the infected cells protects them from CS-mediated lysis (121, 122). CD55-CD97 (expressed on macrophages and granulocytes) interaction promotes T- and B-cell proliferation and secretion of IL-10 and GM-CSF (123). CD55 also inhibits NK cell cytotoxic function (124). The gene discussed is CD55; the disease is malaria.