Genetic CD55 deficiency is associated with paroxysmal nocturnal hemoglobinuria (PNH) (125). Additionally, genetic CD55 deficiency is also associated with hyperactivation of complement and angiopathic thrombosis, and PLE (the CHAPLE syndrome) has been identified as a monogenic form of primary intestinal lymphangiectasia or Waldmann’s disease (WD) (126). The acquired CD59 deficiency is also associated with autoimmune hemolytic anemia (AHA), autoimmune thrombocytopenia (ATP), and systemic lupus lymphopenia (SLL) (127). The gene discussed is CD55; the disease is hyperinsulinemic hypoglycemia, familial, 4.