NR1I3 and Sepsis: To investigate CAR activity in sepsis on a genome-wide level, sham and CLP-treated mice were injected with CAR agonist TCPOBOP or vehicle (corn oil + DMSO), 6h post-surgery (Figure 1A), when CLP mice display hypothermia and significant HNF4α, PPARα and GR activity problems (7–9).