Nevertheless, CAR protein was significantly downregulated in Hnf4aLiver-i-KO mice, both in sham and CLP, compared to Hnf4aflfl mice, but not in Hnf4aflfl mice 8h after CLP (Figure 2F), but was decreased at later stages of sepsis, between 24h and 96h after CLP (Figure 2G). The gene discussed is NR1I3; the disease is Sepsis.