BM-MSCs inhibited the proliferation and cytokine production of T cells by downregulating transcription factors such as T-bet, GATA-3, and c-Maf. BM-MSCs into ovalbumin-induced AD mice led to a significant reduction in cell infiltration in skin lesions, decreased serum IgE levels, and suppressed IL-4 expression in both lymph nodes and skin. The gene discussed is IGHE; the disease is Alzheimer disease.