Approximately 80% of cases, known as primary membranous nephropathy (PMN), is regarded as an organ-specific autoimmune disease in which the identification of a growing range of podocyte autoantigens, such as phospholipase A2 receptor (PLA2R), neutral endopeptidase (NEP), and thrombospondin type-1 domain-containing protein 7A (THSD7A). The gene discussed is THSD7A; the disease is autoimmune disease.