It is concluded that BDNF‐PLGA‐NPs, GDNF‐PLGA‐NPs, and TGF‐ß3‐PLGA‐NPs are promising brain drug delivery carriers for NSC inducers, which could be useful in developing strategies for Parkinson's disease management, particularly when targeted with TRF. This evidence concerns the gene BDNF and Parkinson disease.