Additionally, our analyses of publicly available data from a large number of cell lines covering the different histological subtypes of lung cancer show that there is discordance in metabolite levels and mRNA and protein expression of SLC6A8 in cell lines as compared to tumor tissue results, thus indicating that cell lines are not the optimal model to fully study the potential of SLC6A8 inhibition as a targeted SqCC treatment and understand the mechanisms related to it. The gene discussed is SLC6A8; the disease is lung cancer.