Based on our findings of consistently high creatine levels in SqCC tumor cells compared to other histological subgroups and previous in vitro studies suggesting that SLC6A8 overexpression promotes cell invasion in different types of cancers [35, 37, 38], it appears imminent to also investigate the potential of SLC6A8 inhibitors in SqCC treatment. Here, SLC6A8 is linked to neoplasm.