CRLF3 is located on human chromosome 17, is expressed in most human tissues including the nervous system, and has been associated with differentiation, maturation, cell survival (Wegscheid et al. 2021; Taznin et al. 2022), neuronal dendrite growth (Wilson et al. 2023), immune functions (Yan et al. 2023) and various diseases including amyotrophic lateral sclerosis (ALS) (Cirulli et al. This evidence concerns the gene CRLF3 and amyotrophic lateral sclerosis.