PTEN and endometrial cancer: For example, using a transgenic mouse model of oestrogen, progesterone and PTEN (phosphatase and tensin homologue) deleted on chromosome 10 positive endometrial cancer, Kong et al. demonstrated that tirzepatide reduced endometrial tumour growth by ~60% compared to control, when animals were maintained on either a high or low‐fat diet to generate an obese or lean phenotype, respectively.