However, an analysis of copy number variations revealed that several DHHC family members, including DHHC2, DHHC4, DHHC5, DHHC6, DHHC9, DHHC11, DHHC19, DHHC21, DHHC23 and DHHC24, exhibited more frequent amplifications than deletions across various cancers (Figure S1C,D). Here, ZDHHC5 is linked to cancer.